Specimen and client information
Specimen type
Buccal (cheek) swab
Date reported
29 July 2026
The reports inside this package
This one document contains 4 complete genetic reports. Each was scored on its own, then combined here so you can read everything in one place. Every result further down is labelled with the report it came from.
Pain33 results reported of 33 analytes · 50 recommendations
Headaches & Migraines5 results reported of 5 analytes · 50 recommendations
Nerve Health30 results reported of 36 analytes · 50 recommendations
Inflammation & Autoimmunity80 results reported of 83 analytes · 50 recommendations
About this report
This report reads your DNA and sorts every result into one of five plain-language groups, so you can see at a glance what deserves attention and what does not. Nothing here is a diagnosis. A flagged result means your genetics place you above or below the average person for that trait — a reason to ask a question, not a reason to worry.
What each result group means
Worth a conversation with your doctor
These came back with a higher genetic predisposition than most people. That is not a diagnosis — it means these are the ones worth raising at your next appointment.
Running above the typical range
Your genetics point to these sitting higher than average. Often useful to know, sometimes worth monitoring.
Running below the typical range
Your genetics point to these sitting lower than average. Same idea — context, not alarm.
Working in your favour
Good news. Your genetics look protective or better than average here.
In line with most people
Nothing unusual. These were tested and came back typical — worth having on record.
Your results at a glance
How to read this. A result being flagged does not mean you have a condition — it means your genetics put you above or below the average person for that trait. Of the 133 results here, 24 came back worth discussing with a clinician and 9 came back in your favour. Bring this document to your appointment.
What this package looks at
Pain — We all experience pain from time to time, from stubbing a toe to hurting our knee or having a migraine attack. What makes us all different is the amount of pain we experience and how we handle it. There are lots of reasons for that, one of which is your DNA!
Headaches & Migraines — Headaches and migraines are common issues that can significantly impact daily life, leading to discomfort, pain, and reduced productivity. While environmental factors such as stress, sleep patterns, and diet can trigger headaches, genetics also plays an essential role in determining an
Nerve Health — Nerve health plays a vital role in overall well-being, affecting everything from movement and sensation to cognition and emotional balance. Genetics can significantly influence an individual's susceptibility to various nerve-related conditions, impacting both the peripheral and central
Inflammation & Autoimmunity — Inflammation and autoimmunity are key processes that affect the body’s ability to maintain health and respond to threats. Inflammation is the body's natural response to injury or infection, but chronic inflammation can lead to a variety of health problems, from gut issues to systemic diseases.
What you can actually do
These are ordered by how closely they relate to your flagged results — not generic health advice. Marrow does not prescribe, dose, or tell you to take anything. Diet and lifestyle changes are listed first because they are yours to make. Anything you would swallow is listed separately, by name only, as something to raise with a clinician who knows your history and your medications.
Changes you can make yourself
1
Avoid Food TriggersTry to limit caffeine to per day to avoid migraines.
Relates to: Migraines
2
Avoid Sensory TriggersPractice the techniques learned during sessions at home daily to improve symptoms and manage your condition.
Relates to: Migraines
3
Strength TrainingEngage in strength training exercises, such as weight lifting or bodyweight exercises, for 60 minutes per session, TA 2 to 3 times per week.
Relates to: Parkinson's Disease, Diabetic Neuropathy
4
Nerve Stimulation30 minutesNerve stimulation can be implemented by daily sessions of 15-30 minutes using a device specifically designed for TA this purpose.
Relates to: Cluster Headaches, Migraines, Parkinson's Disease
5
Sleep for 7+ HoursEnsure you allocate enough time in your schedule to achieve a minimum of 7 hours of sleep each night.
Relates to: Migraines, Cluster Headaches
6
Cognitive-Behavioral Therapy (CBT)Engage actively in exercises assigned by your therapist both during sessions and as homework to apply CBT strategies to daily life.
Relates to: Migraines, Chronic Pain, Fibromyalgia, Shoulder & Neck Pain
7
Whole-Food Plant-Based Dietfew weeks to avoid digestive discomfort.
Relates to: Pancreas Inflammation, Eye Inflammation, Myocarditis
8
BiofeedbackPractice the techniques learned during sessions at home daily to improve symptoms and manage your condition.
Relates to: Diabetic Neuropathy, Chronic Pain, Migraines, Shoulder & Neck Pain
9
Yoga30 minutesPractice yoga for at least 20 to 30 minutes a day, most days of the week.
Relates to: Parkinson's Disease, Crohn’s Disease, Pancreas Inflammation, Eye Inflammation
10
Dance30 minutesEngage in dance activities for at least 30 minutes, three times per week.
Relates to: Parkinson's Disease
11
Exercise TherapyBegin by consulting with a physical therapist to assess your condition and create a personalized exercise plan.
Relates to: Long COVID
12
AcupunctureVisit a licensed acupuncturist for a session, typically lasting between 30 to 60 minutes, once or twice a week.
Relates to: Chronic Pain, Migraines, Long COVID, Shoulder & Neck Pain
Worth asking your clinician about
These came up in the research behind your flagged results. They are listed by name so you can ask about them. Marrow is not recommending them, and gives no dose. Supplements interact with prescription medication and with each other — that conversation belongs with your clinician.
1
MagnesiumRelates to: Migraines, Cluster Headaches, Facial Pain, Tremor
2
Maintain Optimal Vitamin D LevelsRelates to: Crohn’s Disease, Thyroid Inflammation, HLA-DOB (Inflammation), Psoriasis
Your headline findings
Of the 133 results in this package, these 8 came back furthest from the population average. Each one below explains what it is, where you sit, and which report it came from. Start here.
MigrainesMore likely
More likely to have migraines based on 109,603 genetic variants we looked at
Your risk is greater than 99% of the population and lower than 1% of the population.
What this actually is
Risk factors include: obesity, depression, stress, being female, blood vessel issues, brain chemical imbalances.
If you have a high genetic risk, take action on modifiable risk factors to help reduce overall risk.
About 16% of Americans regularly have migraines.
What you can do
- Avoid Food Triggers
Try to limit caffeine to per day to avoid migraines. - Avoid Sensory Triggers
Practice the techniques learned during sessions at home daily to improve symptoms and manage your condition. - Sleep for 7+ Hours
Ensure you allocate enough time in your schedule to achieve a minimum of 7 hours of sleep each night.
From your Pain report & Headaches & Migraines
Tonsil InflammationMore likely
Higher predisposition than 99% of people
Your risk is greater than 99% of the population and lower than 1% of the population.
What this actually is
The course of cause is viral or require specific through pain Bacterial can require Recurrent cases of recommendation for of the tonsils. are also common cause.
Ask your clinician about
- Maintain Optimal Vitamin D Levels
- Zinc
Named only. Marrow gives no dose and does not recommend these.
From your Inflammation & Autoimmunity report
Facial PainMore likely
Higher predisposition than 98% of people
Your risk is greater than 98% of the population and lower than 2% of the population.
What this actually is
Diagnosing facial approach that can otolaryngologists, comprehensively and strategies could blocks, or surgery, For instance, sudden, severe resulting from Psychological also play pivotal the need for a plan.
What you can do
- Biofeedback
Practice the techniques learned during sessions at home daily to improve symptoms and manage your condition. - Acupuncture
Visit a licensed acupuncturist for a session, typically lasting between 30 to 60 minutes, once or twice a week.
Ask your clinician about
Named only. Marrow gives no dose and does not recommend these.
From your Pain report & Nerve Health
Droopy EyelidsMore likely
More likely to have droopy eyelids based on 240,468 genetic variants we looked at
Your risk is greater than 97% of the population and lower than 3% of the population.
What this actually is
Eyelid drooping is excess sagging of the upper eyelid.
The eyelid may be sitting lower than it should (ptosis) or drooping due to loose or excess skin (dermatochalasis).
About 60% of the differences in people’s eyelid drooping may be due to genetics.
From your Nerve Health report
Thyroid InflammationMore likely
More likely to have thyroid inflammation based on 348,866 genetic variants we looked at
Your risk is greater than 96% of the population and lower than 4% of the population.
What this actually is
The most common forms of thyroiditis include Hashimoto's thyroiditis, an autoimmune disease where the body's immune system mistakenly attacks the thyroid; postpartum thyroiditis, which can occur after childbirth; and subacute thyroiditis, which usually follows a viral infection.
Diagnosis may involve blood tests to measure thyroid hormone levels, as well as antibody tests to detect autoimmune activity.
Treatment depends on the type and severity of thyroiditis, ranging from observation and symptom management to medications like levothyroxine for hypothyroidism or beta-blockers for hyperthyroidism symptoms.
What you can do
- Autoimmune Protocol (AIP) Diet
Eliminate grains, legumes, nuts, seeds, nightshades, dairy, eggs, coffee, alcohol, refined sugars, refined oils, food additives, and processed foods from your diet for a minimum of 30 days.
Ask your clinician about
- Maintain Optimal Vitamin D Levels
Named only. Marrow gives no dose and does not recommend these.
From your Inflammation & Autoimmunity report
Pancreas InflammationMore likely
More likely to get pancreas inflammation based on 1,669 genetic variants we looked at
Your risk is greater than 95% of the population and lower than 5% of the population.
What this actually is
The pancreas is an organ located behind the stomach that releases crucial enzymes for carbs and fats digestion.
Pancreatitis is inflammation of the pancreas, which can be acute or chronic.
Potential risk factors for pancreatitis include [R, R, R]: Alcohol Cigarette smoking Obesity High blood lipids Certain medications Genetics Genetically predicted higher fasting insulin may be associated with acute and chronic pancreas inflammation.
What you can do
- Whole-Food Plant-Based Diet
few weeks to avoid digestive discomfort. - Acupuncture
Visit a licensed acupuncturist for a session, typically lasting between 30 to 60 minutes, once or twice a week.
Ask your clinician about
Named only. Marrow gives no dose and does not recommend these.
From your Inflammation & Autoimmunity report
Ear PainMore likely
Higher predisposition than 94% of people
Your risk is greater than 94% of the population and lower than 6% of the population.
What this actually is
Ear pain may not itself; it can conditions that otalgia.
Sinus dental issues, and to the ear.
Diagnosis of the comprehensive exam, audiometric studies.
What you can do
- Apply Heat 15 minutes
Do this TA several times a day, ensuring there's at least a 1-hour interval between sessions to avoid skin damage. - Topical Peppermint Oil
Do this no more than 2-3 times daily.
From your Pain report
Statin-Induced Muscle PainMore likely
More likely to have statin-induced muscle pain based on 38 genetic variants we looked at
Your risk is greater than 90% of the population and lower than 10% of the population.
What this actually is
The exact mechanism by which statins cause muscle injury is not completely understood, but it is believed to be related to the depletion of coenzyme Q10, a key component in muscle energy production, or effects on muscle cell membranes and protein synthesis.
Risk factors for developing statin-induced myopathy include higher statin dosages, advanced age, female sex, smaller body frame, concurrent use of certain medications, and pre-existing conditions such as kidney disease.
Most patients see improvement in symptoms after discontinuation of the statin, but the condition necessitates careful balancing of the benefits of cholesterol lowering against the discomfort and potential harm of muscle symptoms.
Ask your clinician about
Named only. Marrow gives no dose and does not recommend these.
From your Pain report
A further 16 results were also flagged for attention. They are listed below and explained in full in the technical version of this report.
Where your genetics are working for you
Not everything in a genetic report is a warning. These came back protective or better than average.
Joint PainLess likely
Less likely to have osteoarthritis based on 385,825 genetic variants we looked at
Your risk is greater than 1% of the population and lower than 99% of the population.
What this actually is
Key Takeaways: Osteoarthritis will affect the majority of people over the age of 55.
So, even with low genetic risk, the overall risk is still high for older people.
About 50% of the differences in people's chances of getting osteoarthritis may be due to genetics.
From your Pain report
Cognitive DeclineLess likely
Less likely to have cognitive decline based on 272,168 genetic variants we looked at
Your risk is greater than 1% of the population and lower than 99% of the population.
What this actually is
Mild cognitive decline is a normal part of aging that can affect cognitive functions such as memory, attention, and problem-solving.
About 60-70% of the differences in people’s cognitive decline may come from genetics.
For example, genetically high total and bioavailable testosterone may be causally associated with larger gray matter volume in men [R, R, R].
From your Nerve Health report
Gut InflammationLess likely
Less likely to have IBD based on 1,671 genetic variants we looked at
Your risk is greater than 8% of the population and lower than 92% of the population.
What this actually is
Risk factors include being under age 30, European ancestry, and smoking.
IBD may cause: diarrhea, fatigue, abdominal pain, bloody stool, weight loss, inflammation, liver damage, and colon cancer.
IBD only affects about 3 in 1000 people worldwide.
From your Inflammation & Autoimmunity report
Everything else that came back
The remaining results, grouped by what they mean. Every one of these is explained in full — with the genes and variants behind it — in the technical version of this report.
Worth a conversation with your doctor (16)
- Painful Urination — More likely, 88th percentile
- Urethra Inflammation — More likely, 88th percentile
- Shoulder & Neck Pain — More likely, 84th percentile
- Eye Inflammation — More likely, 84th percentile
- Cluster Headaches — More likely, 82th percentile
- Tremor — More likely, 82th percentile
- Chronic Pain — More likely, 80th percentile
- Parkinson's Disease — More likely, 70th percentile
- Crohn’s Disease — More likely, 66th percentile
- Psoriasis — More likely, 65th percentile
- Painful Bladder Syndrome — More likely
- Fibromyalgia — More likely
- Diabetic Neuropathy — More likely
- Long COVID — More likely
- Myocarditis — More likely
- Nephritis — More likely
Running above the typical range (10)
- HLA (Inflammation) — Higher activity, 80th percentile
- TRPM8 (Pain) — Higher activity
- KIBRA/WWC1 (Cognition) — Higher activity
- Basophils — Higher levels
- HLA-DOB (Inflammation) — Higher activity
- NF-kB (Inflammation) — Higher activity
- NLRP3 (Gut Inflammation) — Higher activity
- ANKRD55 (Autoimmune) — Higher activity
- ABCB1 (Chronic Lyme) — Higher activity
- HNMT (Histamine) — Higher activity
Running below the typical range (10)
- TRPV1 (Pain) — Lower activity, 15th percentile
- OPRM1 (Endorphins) — Lower activity
- ENPP6 (Cognition) — Lower activity
- SH2B3 (Autoimmunity) — Lower activity
- HNF4A (Gut Inflammation) — Lower activity
- CTLA4 (Autoimmunity) — Lower activity
- IL1B (Inflammation/ Fatigue) — Lower activity
- JAK2 (Gut Inflammation) — Lower activity
- IL8 (Inflammation) — Lower activity
- IL21 (Autoimmunity & Allergies) — Lower activity
Working in your favour (6)
- Optic Nerve Inflammation — Less likely, 19th percentile
- Speech Disorder — Less likely, 14th percentile
- Appendicitis — Less likely, 8th percentile
- Diverticular Disease — Less likely
- Sjogren's Syndrome — Less likely
- IL6R (Weight) — Better genetics
In line with most people (80)
- Back Pain — Typical likelihood, 76th percentile
- Painful Intercourse — Typical likelihood, 74th percentile
- Trigeminal Nerve Pain — Typical likelihood, 68th percentile
- Muscle Pain — Typical likelihood, 68th percentile
- Alzheimer's Disease — Typical likelihood, 65th percentile
- Hip Pain — Typical likelihood, 64th percentile
- Tension Headaches — Typical likelihood, 64th percentile
- Stroke — Typical likelihood, 63th percentile
- Ulcerative Colitis — Typical likelihood, 63th percentile
- Burning Mouth Syndrome — Typical likelihood, 62th percentile
- Multiple Sclerosis — Typical likelihood, 60th percentile
- Carpal Tunnel Syndrome — Typical likelihood, 56th percentile
- Chest Pain (Angina) — Typical likelihood, 52th percentile
- Headache — Typical likelihood, 51th percentile
- Difficulty Swallowing — Typical likelihood, 43th percentile
- Stomach Inflammation — Typical likelihood, 42th percentile
- Celiac Disease — Typical likelihood, 42th percentile
- Rheumatoid Arthritis — Typical likelihood, 40th percentile
- HRH4 (Allergies, Inflammation) — Typical activity, 39th percentile
- Knee Pain — Typical likelihood, 36th percentile
- Inflammation (CRP) — Typical levels, 36th percentile
- Toothache — Typical likelihood, 33th percentile
- Tics — Typical likelihood, 33th percentile
- Eczema — Typical likelihood, 29th percentile
- Stomach Pain — Typical likelihood, 27th percentile
- Paresthesia — Typical likelihood, 23th percentile
- Nerve Compression — Typical likelihood, 22th percentile
- IL-6 — Typical levels, 20th percentile
- Type 1 Diabetes — Typical likelihood, 15th percentile
- Lupus — Typical likelihood, 12th percentile
- Mononeuropathy — Typical likelihood
- Peripheral Neuropathy — Typical likelihood
- Neuropathic Pain — Typical likelihood
- CNR1 (Cannabinoids) — Typical activity
- SCN9A (Pain) — Typical activity
- DAO (Histamine) — Typical activity
- Brain Cancer — Typical likelihood
- Brain Ischemia — Typical likelihood
- Dystonia — Typical likelihood
- Seizures — Typical likelihood
- Bell's Palsy — Typical likelihood
- IDO (Kynurenine) — Typical levels
- Chronic Lyme — Typical likelihood
- Sepsis — Typical likelihood
- Pulmonary Fibrosis — Typical likelihood
- Actinic Keratosis — Typical likelihood
- Meningitis — Typical likelihood
- Sarcoidosis — Typical likelihood
- Rheumatic Fever — Typical likelihood
- Psoriatic Arthritis — Typical likelihood
- Ankylosing Spondylitis — Typical likelihood
- Vitiligo — Typical likelihood
- Alopecia Areata — Typical likelihood
- Systemic Sclerosis — Typical likelihood
- Pemphigus Vulgaris — Typical likelihood
- Behcet’s Disease — Typical likelihood
- IgA Nephropathy — Typical likelihood
- TNF — Typical levels
- White Blood Cells — Typical levels
- Eosinophils — Typical levels
- Monocytes — Typical levels
- Neutrophils — Typical levels
- Erythrocyte Sedimentation Rate — Typical levels
- IgE — Typical levels
- IL-10 — Typical levels
- IL-17 (Th17) — Typical levels
- HLA-B (Autoimmune) — Typical
- HLA-DQ (Inflammation) — Typical activity
- HLA-DRB1 (Autoimmunity) — Typical
- HLA-DQA2 (Inflammation) — Typical
- TLR4 (Inflammation) — Typical activity
- PTPN22 (Autoimmunity) — Typical
- STAT3 (Th1/Th17) — Typical activity
- TNF Gene (Inflammation) — Typical activity
- IL13 (Allergies, Lung Function) — Typical activity
- IL4 (Allergies, Autoimmunity) — Typical activity
- CRP Gene — Typical activity
- PADI4 (Autoimmune) — Typical activity
- IL10 Gene (Autoimmunity) — Typical activity
- SLC22A4 (Gut Inflammation) — Typical genetics
What to do with this
Genetics is a predisposition, not a verdict. The single most useful thing you can do with this document is take it to a clinician and talk through the flagged findings — especially any that line up with symptoms you already have or conditions that run in your family. Nothing here changes: your DNA is the same at 60 as it is today, so this report does not expire.
Methodology
Genotyping was performed on DNA extracted from a buccal (cheek) swab using a genome-wide array. Results are derived from peer-reviewed genome-wide association data and, where applicable, published clinical guidelines. Each report was scored independently against its own reference set. Percentile figures describe where your result sits relative to a reference population.
Limitations
This is a laboratory-developed test. It has not been cleared or approved by the U.S. Food and Drug Administration. Genotyping does not detect all variants in the genes assessed; the absence of a flagged result does not exclude risk. Predisposition is probabilistic and is modified by environment, lifestyle, ancestry and family history. Results must be interpreted by a qualified healthcare professional and must not be used alone to diagnose, treat, or alter any medication regimen. Marrow does not recommend, prescribe, or dose any supplement or medication.